ื—ื–ืจื” ืœื‘ืœื•ื’
Methylcobalamin
ื•ื™ื˜ืžื™ืŸ B12
ื˜ื‘ืขื•ื ื™ื
ืžื—ืกื•ืจ B12
ืžืขืจื›ืช ืขืฆื‘ื™ื
ืกืคื™ื’ื” ืชืช-ืœืฉื•ื ื™ืช
ืขื™ื™ืคื•ืช

ื•ื™ื˜ืžื™ืŸ B12 โ€” ื”ืžื“ืจื™ืš ื”ืžื“ืขื™: ืžื—ืกื•ืจ, ืกืคื™ื’ื” ืชืช-ืœืฉื•ื ื™ืช ื•-Methylcobalamin

ื›ืœ ืžื” ืฉืฆืจื™ืš ืœื“ืขืช ืขืœ ื•ื™ื˜ืžื™ืŸ B12: ืžื™ ื‘ืกื™ื›ื•ืŸ ืœืžื—ืกื•ืจ, ืœืžื” ืกืคื™ื’ื” ืชืช-ืœืฉื•ื ื™ืช ืขื“ื™ืคื”, ื•ืžื” ื”ื”ื‘ื“ืœ ื‘ื™ืŸ Methylcobalamin ืœ-Cyanocobalamin. ืžื‘ื•ืกืก ืžื—ืงืจื™ื ืž-PubMed.
ื’ืœืขื“.ื ืคื•ืจืกื ื‘ืชืืจื™ืš: 27/06/2025
ื•ื™ื˜ืžื™ืŸ B12 โ€” ืชื•ืกืฃ ืชื–ื•ื ื” ืœืื ืจื’ื™ื” ื•ืžืขืจื›ืช ืขืฆื‘ื™ื

ื•ื™ื˜ืžื™ืŸ B12 ื”ื•ื ืื—ื“ ื”ื•ื•ื™ื˜ืžื™ื ื™ื ื”ื ื—ืงืจื™ื ื‘ื™ื•ืชืจ ื‘ืขื•ืœื โ€” ื•ืื—ื“ ื”ืฉื›ื™ื—ื™ื ื‘ื™ื•ืชืจ ืœื—ืกืจ. ื‘ื ื™ื’ื•ื“ ืœืžืจื‘ื™ืช ื”ื•ื™ื˜ืžื™ื ื™ื, B12 ืขืฉื•ื™ ืœื’ืจื•ื ืœื ื–ืง ืขืฆื‘ื™ ื‘ืœืชื™ ื”ืคื™ืš ืื ื”ื—ืกืจ ื ืžืฉืš ืœืื•ืจืš ื–ืžืŸ. ื”ื ื” ื›ืœ ืžื” ืฉืฆืจื™ืš ืœื“ืขืช, ืžื‘ื•ืกืก ืžื—ืงืจ ืขื“ื›ื ื™.

ืžื” ื–ื” ื•ื™ื˜ืžื™ืŸ B12 ื•ืžื“ื•ืข ื”ื•ื ื›ื” ืงืจื™ื˜ื™?

ื•ื™ื˜ืžื™ืŸ B12 (ืงื•ื‘ืœืžื™ืŸ) ื”ื•ื ื•ื™ื˜ืžื™ืŸ ืžืกื™ืก ื‘ืžื™ื ืฉื”ื’ื•ืฃ ืื™ื ื• ืžืกื•ื’ืœ ืœื™ื™ืฆืจ ื‘ืขืฆืžื• โ€” ื—ื™ื™ื‘ื™ื ืœืงื‘ืœ ืื•ืชื• ืžื”ืชื–ื•ื ื” ืื• ืžืชื•ืกืคื™ื. ื”ื•ื ืžืžืœื ืชืคืงื™ื“ื™ื ืžืจื›ื–ื™ื™ื:

  • ืžืขืจื›ืช ืขืฆื‘ื™ื โ€” B12 ื ื“ืจืฉ ืœืกื™ื ืชื–ืช ื”ืžื™ืืœื™ืŸ, ื”ื ื“ืŸ ื”ืžื’ืŸ ื”ืขื•ื˜ืฃ ืืช ืกื™ื‘ื™ ื”ืขืฆื‘. ืžื—ืกื•ืจ ืžื•ื‘ื™ืœ ืœื”ื™ื“ืจื“ืจื•ืช ืขืฆื‘ื™ืช ืžื“ื™ื“ื”. (Stabler SP, Allen RH. Annu Rev Nutr. 2004. PMID: 15189132)
  • ื™ื™ืฆื•ืจ ืชืื™ ื“ื ืื“ื•ืžื™ื โ€” B12 ื—ื™ื•ื ื™ ืœืกื™ื ืชื–ืช DNA ื‘ืชืื™ ื”ื“ื. ืžื—ืกื•ืจ ื’ื•ืจื ืœืื ืžื™ื” ืžื’ืœื•ื‘ืœืกื˜ื™ืช โ€” ืชืื™ ื“ื ื’ื“ื•ืœื™ื ื•ืœื ืชืงื™ื ื™ื ืฉื ื•ืฉืื™ื ืคื—ื•ืช ื—ืžืฆืŸ.
  • ืžื˜ื‘ื•ืœื™ื–ื ื”ื•ืžื•ืฆื™ืกื˜ืื™ืŸ โ€” B12 ื”ื•ื ืงื•ืคืงื˜ื•ืจ ื‘ื”ืžืจืช ื”ื•ืžื•ืฆื™ืกื˜ืื™ืŸ ืœืžืชื™ื•ื ื™ืŸ. ืจืžื•ืช ื”ื•ืžื•ืฆื™ืกื˜ืื™ืŸ ื’ื‘ื•ื”ื•ืช ืงืฉื•ืจื•ืช ืœืกื™ื›ื•ืŸ ืงืจื“ื™ื•ื•ืกืงื•ืœืจื™ ื•ืœื™ืจื™ื“ื” ืงื•ื’ื ื™ื˜ื™ื‘ื™ืช. (Refsum H et al. Annu Rev Med. 1998. PMID: 9509257)
  • ืชืคืงื•ื“ ืงื•ื’ื ื™ื˜ื™ื‘ื™ โ€” ืžื—ืงืจ ืž-Neurology ืžืฆื ืฉืžื—ืกื•ืจ ื‘-B12 ืงืฉื•ืจ ืœืงืฆื‘ ืžื”ื™ืจ ื™ื•ืชืจ ืฉืœ ืื•ื‘ื“ืŸ ื ืคื— ื”ืžื•ื—. (Vogiatzoglou A et al. Neurology. 2008. DOI: 10.1212/01.wnl.0000326723.44908.e4)

ืžื™ ื ืžืฆื ื‘ืกื™ื›ื•ืŸ ืœืžื—ืกื•ืจ?

ื ืชื•ืŸ ื—ืฉื•ื‘: ืžื—ืงืจ ื’ื“ื•ืœ ืž-American Journal of Clinical Nutrition ืžืฆื ืฉื›-6% ืžื”ืžื‘ื•ื’ืจื™ื ืžืชื—ืช ืœื’ื™ืœ 60 ื•-20% ืžืขืœ ื’ื™ืœ 60 ืกื•ื‘ืœื™ื ืžืžื—ืกื•ืจ ื‘-B12. ืืฆืœ ื˜ื‘ืขื•ื ื™ื ืฉืื™ื ื ื ื•ื˜ืœื™ื ืชื•ืกืฃ โ€” ื”ืฉื™ืขื•ืจ ืžื’ื™ืข ืœ-52โ€“86%.
(Allen LH. Am J Clin Nutr. 2009. PMID: 19116332)

ืงื‘ื•ืฆื•ืช ื‘ืกื™ื›ื•ืŸ ืžื•ื’ื‘ืจ:

  • ืฆืžื—ื•ื ื™ื™ื ื•ื˜ื‘ืขื•ื ื™ื โ€” B12 ื ืžืฆื ื›ืžืขื˜ ืืš ื•ืจืง ื‘ืžื–ื•ืŸ ืžื”ื—ื™
  • ืžื‘ื•ื’ืจื™ื ืžืขืœ ื’ื™ืœ 50 โ€” ืกืคื™ื’ืช B12 ื™ื•ืจื“ืช ืขื ื”ื’ื™ืœ ื‘ืฉืœ ื™ืจื™ื“ื” ื‘ื—ื•ืžืฆืช ืงื™ื‘ื”
  • ื ื•ื˜ืœื™ ืžื˜ืคื•ืจืžื™ืŸ โ€” ืชืจื•ืคืช ื”ืกื•ื›ืจืช ืžืคืจื™ืขื” ืœืกืคื™ื’ืช B12 (Aroda VR et al. Diabetes Care. 2016. PMID: 27208353)
  • ื ื•ื˜ืœื™ ืžืขื›ื‘ื™ ืžืฉืื‘ืช ืคืจื•ื˜ื•ืŸ (PPIs) โ€” ืžืคื—ื™ืชื™ื ื—ื•ืžืฆื™ื•ืช ื”ื ื—ื•ืฆื” ืœืฉื—ืจื•ืจ B12 ืžืžื–ื•ืŸ
  • ืื ืฉื™ื ืขื ืžื—ืœื•ืช ืžืขื™ โ€” ืงืจื•ื”ืŸ, ืฆืœื™ืืง ื•ืžื—ืœื•ืช ืกืคื™ื’ื” ืื—ืจื•ืช

ืชืกืžื™ื ื™ื ืฉืขืฉื•ื™ื™ื ืœื”ืฆื‘ื™ืข ืขืœ ืžื—ืกื•ืจ

ืžื—ืกื•ืจ ื‘-B12 ืžืชืคืชื— ืœืื˜ ื•ืœื›ืŸ ืœืจื•ื‘ ืžืื•ื—ืจ ืžื“ื™ ืœื’ื™ืœื•ื™. ืชืกืžื™ื ื™ื ืฉื›ื™ื—ื™ื:

  • ืขื™ื™ืคื•ืช ื›ืจื•ื ื™ืช ืฉืื™ื ื” ื—ื•ืœืคืช ืขื ืฉื™ื ื”
  • ืขืจืคืœ ืžื•ื—ื™, ืงื•ืฉื™ ื‘ืจื™ื›ื•ื– ื•ื–ื™ื›ืจื•ืŸ
  • ื ื™ืžื•ืœ ื•ืขืงืฆื•ืฅ ื‘ื™ื“ื™ื™ื ื•ื‘ืจื’ืœื™ื™ื
  • ื—ื™ื•ื•ืจื•ืŸ ื•ื—ื•ืœืฉื” ื›ืœืœื™ืช
  • ืฉื™ื ื•ื™ื™ื ื‘ืžืฆื‘ ื”ืจื•ื—, ืขืฆื‘ื ื•ืช
  • ื›ืื‘ ื•ื“ืœืงืช ื‘ืœืฉื•ืŸ (glossitis)

ื—ืฉื•ื‘: ื‘ื“ื™ืงืช ื“ื ืจื’ื™ืœื” ืื™ื ื” ืชืžื™ื“ ืžืกืคื™ืงื” โ€” ื ื™ืชืŸ ืœืกื‘ื•ืœ ืžืžื—ืกื•ืจ B12 ืคื•ื ืงืฆื™ื•ื ืœื™ ื’ื ืขื ืจืžื•ืช "ื ื•ืจืžืœื™ื•ืช" ื‘ื“ื. ื”ื‘ื“ื™ืงื” ื”ืจื’ื™ืฉื” ื™ื•ืชืจ ื›ื•ืœืœืช ืžื“ื™ื“ืช ื”ื•ืžื•ืฆื™ืกื˜ืื™ืŸ ื•-MMA (ืžืชื™ืœืžืœื•ื ื™ืช ื—ื•ืžืฆื”).

ืกืคื™ื’ื” ืชืช-ืœืฉื•ื ื™ืช โ€” ืœืžื” ื–ื” ืžืฉื ื”?

๐Ÿ”ฌ ืžื—ืงืจ ื”ืฉื•ื•ืืชื™ โ€” Sharabi et al., 2003:
ืžื—ืงืจ ืฉืคื•ืจืกื ื‘-British Journal of Clinical Pharmacology ื”ืฉื•ื•ื” ืกืคื™ื’ืช B12 ื“ืจืš ืžืฆื™ืฆื” ืชืช-ืœืฉื•ื ื™ืช ืœืขื•ืžืช ื‘ืœื™ืขื” ืจื’ื™ืœื”. ื”ืžืžืฆืื™ื ื”ืจืื• ืฉืžืฆื™ืฆื” ืชืช-ืœืฉื•ื ื™ืช ื™ื›ื•ืœื” ืœื”ื™ื•ืช ื™ืขื™ืœื” ื‘ืื•ืชื” ืžื™ื“ื” ื›ืžื• ื”ื–ืจืงื•ืช B12 โ€” ื’ื ืืฆืœ ืื ืฉื™ื ืขื ื’ื•ืจื ืคื ื™ืžื™ ืœืงื•ื™ (intrinsic factor), ืฉื‘ืžืฆื‘ ืจื’ื™ืœ ืœื ื™ื›ื•ืœื™ื ืœืกืคื•ื’ B12 ื“ืจืš ื”ืขื™ื›ื•ืœ.
DOI: 10.1046/j.1365-2125.2003.01907.x

ืกืคื™ื’ื” ืชืช-ืœืฉื•ื ื™ืช ืขื•ืงืคืช ืืช ืžืขืจื›ืช ื”ืขื™ื›ื•ืœ ืœื—ืœื•ื˜ื™ืŸ โ€” ื”ื•ื•ื™ื˜ืžื™ืŸ ื ืกืคื’ ื™ืฉื™ืจื•ืช ืœื–ืจื ื”ื“ื ื“ืจืš ืจื™ืจื™ื•ืช ื”ืคื”. ื–ื” ื™ืชืจื•ืŸ ืžืฉืžืขื•ืชื™ ืขื‘ื•ืจ:

  • ืื ืฉื™ื ืขื ืกืคื™ื’ื” ื™ืจื•ื“ื” ื‘ืžืขื™
  • ืžื‘ื•ื’ืจื™ื ืขื ื™ืจื™ื“ื” ื‘ื—ื•ืžืฆื™ื•ืช ื”ืงื™ื‘ื”
  • ืื ืฉื™ื ื”ืจื•ืฆื™ื ืกืคื™ื’ื” ืžื”ื™ืจื” ื•ื™ืขื™ืœื”

Methylcobalamin โ€” ื”ืฆื•ืจื” ื”ืคืขื™ืœื”

ืœื ื›ืœ B12 ื–ื”ื”. ื™ืฉ ืฉืชื™ ืฆื•ืจื•ืช ืขื™ืงืจื™ื•ืช:

  • Methylcobalamin โ€” ื”ืฆื•ืจื” ื”ืคืขื™ืœื” ื‘ื™ื•ืœื•ื’ื™ืช. ื”ื’ื•ืฃ ืžืฉืชืžืฉ ื‘ื” ื™ืฉื™ืจื•ืช, ืœืœื ืฆื•ืจืš ื‘ื”ืžืจื” ื›ื™ืžื™ืช. ืžื•ืขื“ืคืช ืœืชืžื™ื›ื” ื‘ืชืคืงื•ื“ ืขืฆื‘ื™.
  • Cyanocobalamin โ€” ืฆื•ืจื” ืกื™ื ืชื˜ื™ืช ื–ื•ืœื” ื™ื•ืชืจ ืฉื”ื’ื•ืฃ ื—ื™ื™ื‘ ืœื”ืžื™ืจ. ืคื—ื•ืช ื™ืขื™ืœื” ืœืื ืฉื™ื ืขื ืคื•ืœื™ืžื•ืจืคื™ื–ื MTHFR.

B12 ืฉืœ Harmony โ€” ืžืฆื™ืฆื” ืชืช-ืœืฉื•ื ื™ืช ืขื Methylcobalamin

ืชื•ืกืฃ B12 ืฉืœ Harmony ืžื’ื™ืข ื‘ืฆื•ืจืช ื˜ื‘ืœื™ื™ืช ืžืฆื™ืฆื” ืชืช-ืœืฉื•ื ื™ืช ืขื Methylcobalamin โ€” ื”ืฆื•ืจื” ื”ืคืขื™ืœื”, ื‘ืกืคื™ื’ื” ืžื™ื˜ื‘ื™ืช:

  • โœ… ืžืชืžื•ืกืก ืžืชื—ืช ืœืœืฉื•ืŸ โ€” ืกืคื™ื’ื” ื™ืฉื™ืจื” ืœื“ื
  • โœ… Methylcobalamin โ€” ื”ืฆื•ืจื” ื”ืคืขื™ืœื” ื‘ื™ื•ืœื•ื’ื™ืช
  • โœ… ืœืœื ื’ืœื•ื˜ืŸ, ื›ืฉืจ, ืžืชืื™ื ืœื˜ื‘ืขื•ื ื™ื
  • โœ… ืœืœื ื‘ืœื‘ื•ืœ โ€” ืžื™ื ื•ืŸ ื™ื•ืžื™ ืคืฉื•ื˜
  • โœ… ืžื™ื•ืฆืจ ื‘ื”ืชืื ืœืชืงื ื•ืช ืžืฉืจื“ ื”ื‘ืจื™ืื•ืช ื”ื™ืฉืจืืœื™

ืชืžื™ื›ื” ื™ื•ืžื™ื•ืžื™ืช ื‘ืžืขืจื›ืช ื”ืขืฆื‘ื™ื, ื”ืื ืจื’ื™ื” ื•ื”ื–ื™ื›ืจื•ืŸ

B12 ืฉืœ Harmony โ€” Methylcobalamin ืชืช-ืœืฉื•ื ื™. ืคืฉื•ื˜, ื™ืขื™ืœ, ืžื‘ื•ืกืก ืžื—ืงืจ.

ืœืจื›ื™ืฉืช B12 ืฉืœ Harmony

๐Ÿ“š ืžืืžืจื™ื ืงืฉื•ืจื™ื

* ืชื•ืกืฃ ืชื–ื•ื ื” ืื™ื ื• ืชืจื•ืคื” ื•ืื™ื ื• ืžื™ื•ืขื“ ืœืื‘ื—ืŸ, ืœื˜ืคืœ, ืœืจืคื ืื• ืœืžื ื•ืข ืžื—ืœื” ื›ืœืฉื”ื™. ื”ืžื™ื“ืข ื‘ืืชืจ ื–ื” ื”ื•ื ืœืžื˜ืจื•ืช ืžื™ื“ืข ื‘ืœื‘ื“ ื•ืื™ื ื• ืžื”ื•ื•ื” ื™ื™ืขื•ืฅ ืจืคื•ืื™. ื™ืฉ ืœื”ืชื™ื™ืขืฅ ืขื ืจื•ืคื ืœืคื ื™ ื ื˜ื™ืœืช ื›ืœ ืชื•ืกืฃ, ื‘ืžื™ื•ื—ื“ ื‘ื”ืจื™ื•ืŸ, ื”ื ืงื” ืื• ื‘ืขืช ื ื˜ื™ืœืช ืชืจื•ืคื•ืช.

ืžืืžืจื™ื ื ื•ืกืคื™ื ืฉื™ื›ื•ืœื™ื ืœืขื ื™ื™ืŸ ืื•ืชืš

B12 - ืžืฉื•ืœื‘
ร—
B12 - ืžืฉื•ืœื‘ B12 - ืžืฉื•ืœื‘

ืœืงื‘ืœืช ื”ื˜ื‘ื” ืœื”ื–ืžื ืช B12 ื‘ื ื•ืกื—ื ื™ื™ื—ื•ื“ื™ืช ืœื—ืฆื• ื›ืืŸ

ืœืงื‘ืœืช ื”ื˜ื‘ื” ืœื”ื–ืžื ืช B12 ื‘ื ื•ืกื—ื ื™ื™ื—ื•ื“ื™ืช ืœื—ืฆื• ื›ืืŸ